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Contraindicated (1)pentobarbital will minimize the extent or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with potent CYP3A4 inducers may end up in lowered serum concentrations and loss of antimalarial efficacypentobarbital will reduce the extent or effect of osilodrostat by affe